This advisory addresses the issue of patents in the field of bioinformatics, one of the hottest technologies. As the bioinformatics industry continues to urge forward, two trends have emerged- the role and importance of bioinformatics patents continues to increase and the number of bioinformatics patents is rapidly growing. The advisory further explores these trends, discussing what aspects of bioinformatics can be patented and why bioinformatics companies should focus on patents. Offensive uses, cross-licensing, creating leverage in business deals and defensive uses are also addressed.